The AUC of serum HBP, Lac, and hs-CRP for predicting the prognosis of sepsis patients were 0.858 (95% CI: 0.763–0.953), 0.694 (95% CI: 0.589–0.799), and 0.843 (95% CI: 0.759–0.927). Here, CRP is linked to Sepsis.