NFE2L3 and neoplasm: The average tumor weights of different groups at the endpoint were 1.76 ± 0.33 g (HT29, DMSO), 2.23 ± 0.45 g (HT29/Nrf3, DMSO), 0.96 ± 0.26 g (HT29/Nrf3, 5-FU), and 0.56 ± 0.15 g (HT29, 5-FU) (Figure 6(c)).