NPM1 and acute myeloid leukemia: Classification of AML subtype is contribute to the development of new therapeutic approaches.1 The most frequently mutated genes in AML is Nucleophosmin-1 (NPM1) which found in nearly one-third of newly diagnosed cases both in younger and older adults.2 Nucleophosmin-1 (NPM1) defined as a nucleus cytoplasm shuttling protein that is ubiquitously expressed and is highly conserved and this protein has been shown to contribute to many basic cellular processes such as ribosomes biosynthesis, regulation of centrosome function, genome stability, DNA duplication, transcriptional regulation.