The results (Table 1) showed that the USH2A mutation (HR = 1.909; 95% CI = 1.088–3.351; p = 0.024) and MUC4 mutation (HR = 2.232; 95% CI = 1.301–3.829; p = 0.004) were associated with a poor prognosis of COAD; thus, they could be considered independent risk factors. This evidence concerns the gene MUC4 and colon adenocarcinoma.