A multidimensional and stable isotope labelled q3D LC-MS quantitative plasma proteomics enabled discovery of novel protein biomarkers and 5-protein signature comprising of complement factor H related 5 (CFHR5), interleukin enhancer binding factor 2 (ILF2), leucine-rich alpha-2 glycoprotein (LRG1), LPS-binding protein (LBP), serum amyloid A (SAA), plasma C-reactive protein (CRP) and E3 ubiquitin-protein ligase listerin (LTN) to improve diagnostic accuracy of TB (49). The gene discussed is CFHR5; the disease is tuberculosis.