RAG2 and colitis: While 3% DSS was not sufficient to trigger weight loss independent of the T-bet genotype, 5% DSS induced colitis in those mice, however the phenotype was less severe in T-bet deficient mice (Supplementary Figures 6C, D) In contrast, BALB/c-background Rag2-/-xγc-/- and Rag2-/-xγc-/-xTbx21-/- exposed to 5% DSS were resistant to colitis and only experienced weight loss after 7-8 days, which was independent of T-bet expression (Supplementary Figure 6E).