As shown in Figure 10A, NMI infection induced a significant body weight loss in unimmunized WT and NMII-immunized B cell-deficient and T cell-deficient mice at different times post challenge, but there was no body weight loss in NMII-immunized WT, CD4+ T cell-deficient, and CD8+ T cell-deficient mice. The gene discussed is CD4; the disease is infection.