The expressions of RIPK2, RBCK1, TRAFD1, SOD2, NMI, MT2A, CD86, and CD74 were significantly increased in the advanced stages of ccRCC, and the expressions of RIPK2, RBCK1, NOD1, and CDKN1A were significantly increased in the advanced stages of pRCC. This evidence concerns the gene TRAFD1 and nonpapillary renal cell carcinoma.