The expressions of RIPK2, RBCK1, TRAFD1, SOD2, NMI, MT2A, CD86, and CD74 were significantly increased in the advanced stages of ccRCC, and the expressions of RIPK2, RBCK1, NOD1, and CDKN1A were significantly increased in the advanced stages of pRCC. The gene discussed is SOD2; the disease is nonpapillary renal cell carcinoma.