Therefore, it is worth exploring which cells expressing IFN-γ in the tumor microenvironment mediate the resistance of immunotherapy and the mechanism of IFN-γ-mediated “immune-cold” tumor turning to “immune-hot,” in order to design better treatment methods to balance antitumor and immune escape capacities of RCC (31, 32). The gene discussed is IFNG; the disease is renal cell carcinoma.