The immune activation of IFN-γ on tumor cells is largely attributed to tumor cells, monocytes, endothelial cells, and fibroblasts inducing tumor cells to express MHC class I and secrete CXCL9, CXCL10, and CXCL11 to promote lymphocyte migration and inhibition of angiogenesis (28–30). This evidence concerns the gene CXCL10 and neoplasm.