The immune-related genes BIRC5, INHBE, and IL20RB were upregulated in a TMBhigh group and were associated with a poor prognosis (25), and a combination of PD-1 and CTLA-4 blockers was suggested for the treatment of advanced renal cell carcinoma with aberrations (26). This evidence concerns the gene PDCD1 and hereditary clear cell renal cell carcinoma.