To optimize the predictive models and enhance clinical translation efficiency based on the prognostic implications of the 24 IFN-γ response signatures, we selected the five IFN-γ related genes (MT2A, RBCK1, PNP, LATS2, PFKP) with the most prognostic significance for ccRCC for use in a nomogram. Here, LATS2 is linked to nonpapillary renal cell carcinoma.