TP53 and colorectal carcinoma: To further clarify the genetic alterations in UC patients, various of studies depicted the genomic and molecular landscape of inflammatory bowel disease (IBD)-associated CRC, and shown that the main genomic alterations in IBD-CRC, including p53 mutation, p53 loss of heterozygosity (LOH), chromosomic instability, and a high incidence of MSI accompanied by telomere shortening (O’Sullivan et al., 2002), in long standing UC patients with severe inflammation, thus reflecting genomic instability caused by repeated inflammatory stress (Park et al., 1998; Ishitsuka et al., 2001).