VDAC1 and type 2 diabetes mellitus: A previous study showed that mitochondria-associated endoplasmic reticulum membrane (MAM) integrity, VDAC1-inositol 1,4,5-trisphosphate receptor type1 (IP3R1) interactions are decreased in obese and T2DM patients, suggesting that metabolic disorders alter Ca2+ handling by these organelles (Tubbs et al., 2018).