Therefore, in this study, we evaluated the potential anti-inflammatory effect of IPEA in LPS-induced sepsis of mice, and further explored whether its underlying mechanism involved GABAAR. Our results showed that IPEA significantly suppressed the expression levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α in both the serum and lung tissue of the septic mouse models. The gene discussed is TNF; the disease is Sepsis.