AGT and heart failure: However, there also exist some other studies indicating an opposite view that miR-132 levels are down-regulated in the heart of heart failure rats and Ang-II treated CFs and upregulation of miR-132 exerts inhibitory effects on cardiac fibrosis in MI-induced heart failure rats, doxorubicin-induced dilated cardiomyopathy rat, and canine model of atrial fibrillation (Qiao et al., 2017; Zhang et al., 2019; Wang et al., 2020).