Nuclear factor erythroid 2-related factor 2 (NRF2), is a basic leucine zipper protein that promotes an array of antioxidant genes and phase II detoxifying enzymes expression by binding to antioxidant response elements, playing an important role in maintaining the normal function of cardiomyocytes and cardiac fibroblasts and preventing maladaptive cardiac remodeling and heart failure (Li et al., 2009; Chen and Maltagliati, 2018). The gene discussed is NFE2L2; the disease is heart failure.