AKT1 and ovarian cancer: Ovary cancer cells use lipid metabolism in ascites or retinal microenvironment to enhanced ovarian cancer metastasis and aggressiveness through different signaling pathways, such as lipogenesis and signaling activation mediated by AMPK, enhanced arachidonic acid metabolism by PI3K/Akt/mTOR pathway, et al. (Lyu et al., 2018; Chen et al., 2019a).