MAPT and early-onset autosomal dominant Alzheimer disease: The latest research shows that Tau pathology is closely associated with affected synaptic density and synaptic function in Alzheimer’s disease, which is verified by [18F]flortaucipir PET), [11C]UCB-J PET and magnetoencephalography (MEG) in Alzheimer’s disease (Coomans et al., 2021).