In an experimental rat subarachnoid hemorrhage model, Chen et al. demonstrated that delivery of exosomal miR-124 from neurons to MG was significantly reduced, accompanied by increased C/EBPα expression, which was inhibited by CX3CL1/CX3CR1 overexpression; thus, the CX3CL1/CX3CR1 axis may exert protective roles in subarachnoid hemorrhage by promoting the delivery of exosomal miR-124 to MG and inhibiting MG activation as well as the neuroinflammatory response (Chen et al., 2020). This evidence concerns the gene CX3CL1 and subarachnoid hemorrhage.