Exogenous delivery of miR-124 inhibited MEKK3 and p-p65 expression and attenuated the activation of MG in the substantia nigra pars compacta of MPTP-treated mice, indicating miR-124 can inhibit neuroinflammation during the development of PD by regulating the MEKK3/NF-κB signaling pathways (Yao et al., 2018). The gene discussed is MAP3K3; the disease is Parkinson disease.