cAMP-response element-binding protein1 (CREB1) was identified as a target gene of miR-124, and miR-124 overexpression repressed CREB1 expression, which is a key regulator in epileptogenesis, indicating miR-124 is involved in the pathogenesis of epilepsy by regulating CREB1 expression (Wang W. et al., 2016). This evidence concerns the gene CREB1 and epilepsy.