In addition, the experimental sepsis induced more severe brain damages, including microglial activation and neuronal death, in hyperglycemic mice compared to insulin-treated mice (Sonneville et al., 2015), suggesting that poor glycemic control renders CNS more vulnerable to neuroinflammation, and insulin may protect the brain from sepsis-induced neuroinflammation and neuronal damages (Hache et al., 2015). This evidence concerns the gene INS and Sepsis.