PINK1 and neuroblastoma: While f-PINK1 expression alone can suppress toxin-induced macroautophagy in SH-SY5Y cells, there is precedence for a role of c-PINK1 in suppressing macroautophagy/mitophagy induced by oxidative stress given that transient expression ΔN-PINK1 is sufficient to suppress macroautophagy induced by loss of endogenous PINK1 in neuroblastoma cells (Dagda et al., 2009).