In the context of oxidative stress and in PD, the PINK1 knockout mouse exhibits loss of neuronal development markers such as GFAP, a phenotype that is associated with significantly reduced global PKA activity in the brain, cellular pathology that coincides with significantly reduced mitochondrial content and dendritic arbors in midbrain dopamine neurons (Das Banerjee et al., 2017). Here, PINK1 is linked to Parkinson disease.