Among genetic variations in the human genome, single-nucleotide polymorphisms (SNPs) in the first intron of the Fat mass and obesity-associated gene (FTO) were identified to be most highly associated with obesity risk (Dina et al., 2007; Frayling et al., 2007; Cecil et al., 2008; Speakman et al., 2008; Tanofsky-Kraff et al., 2009). The gene discussed is FTO; the disease is obesity disorder.