Rather, bulk RNA sequencing conducted on DLBCL cells retrieved from mice under ibrutinib, or exposed in vitro to ibrutinib, points to Bcl-XL and Bcl-2A1 as alternative Bcl-2 family members that can substitute for Bcl-2 unless transcriptionally downregulated by BTK inhibition. Here, BCL2 is linked to diffuse large B-cell lymphoma.