BCL2 and diffuse large B-cell lymphoma: Aberrant Bcl-2 expression in DLBCL can be caused by either the chromosomal t(14;18) translocation, which juxtaposes BCL2 to IgH gene enhancer elements and affects ~20% of GCB-DLBCL but is rare in ABC-DLBCL, or by BCL2 amplification in ABC-DLBCL [10].