Simple immunohistochemical analysis of Bcl-2 and of phosphorylated or nuclear P65 as a marker of constitutive NF-κB activation are potentially useful indicators of efficacy of the combinatorial treatment; six of 39 patients in our DLBCL patient cohort that were evaluable for both markers had evidence of both high Bcl-2 expression and of nuclear distribution of NF-κB P65. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.