Bcl-2low cell lines and primary tumors from DLBCL patients tend to alternatively express Mcl-1, which is inversely correlated with Bcl-2 at the transcript level; the DLBCL subtype featuring NOTCH2 mutations and BCL6 translocations (termed “BN2” [10]) is particularly prone to high Mcl-1 (and low Bcl-2) expression. Here, BCL2 is linked to diffuse large B-cell lymphoma.