Interestingly, the Mcl-1 inhibitor S63845, a selective BH3-mimetic [18], was effective at killing DLBCL cells with no or low expression of Bcl-2 only, and synergized with venetoclax in killing a DLBCL cell line with co-expression of both Bcl-2 family proteins (Fig. 3f). Here, BCL2 is linked to diffuse large B-cell lymphoma.