Sleep-disordered breathing possibly via hypoxia, inflammation, and sleep disruption/deprivation could contribute to Alzheimer’s disease processes, e.g., increase of Aβ production and aggregation, suppression of glymphatic clearance of Alzheimer’s disease pathogenic proteins (τ, Aβ) and oxidative stress, inflammation, and synaptic damage134,163. The gene discussed is TBXT; the disease is Alzheimer disease.