IFNG and neoplasm: In this model, the reduced anti-tumor immunity of sleep-deprived animals was also indexed by the reduced number of antigen-presenting cells (dendritic cells) in the lymph nodes, as well as by the decreased effector CD4 T-cell numbers and corresponding cytokine profile (decreased IFN-γ), resulting in lowered Th1 response of Th cells, i.e., the most effective immune response against tumors.