Likewise, regarding the anti-tumor immune action, Th1 response supports cytotoxic lymphocytes and tumor cells destruction with the potential of elimination or control of tumor cell growth, so that a type 1 adaptive immune response (increased antigen presentation, IFN-γ signaling, and T-cell receptor signaling) may be associated with an improved survival or prognosis241,242. This evidence concerns the gene IFNG and neoplasm.