In line with this result, we did not observe any coding, promoter or 5′/3′ untranslated region (UTR) mutations in driver genes of HCC and CCA (obtained from Intogen; see “Methods” section), except for one missense variant in an alcoholic cirrhosis ICO sample (TERT c.1588C>G) (Fig. 4). This evidence concerns the gene TERT and cholangiocarcinoma.