Furthermore, CBD suppresses the expression of skin differentiation genes, drives cells to acquire a less-differentiated state20 and acts via peroxisome proliferator-activated receptor gamma (PPARγ), which has been implicated in various pathological states, including adipogenesis, diabetes, atherogenesis, neurodegenerative disease, lung cancer and leukaemia21–23. The gene discussed is PPARG; the disease is neurodegenerative disease.