Furthermore, CBD suppresses the expression of skin differentiation genes, drives cells to acquire a less-differentiated state20 and acts via peroxisome proliferator-activated receptor gamma (PPARγ), which has been implicated in various pathological states, including adipogenesis, diabetes, atherogenesis, neurodegenerative disease, lung cancer and leukaemia21–23. This evidence concerns the gene PPARG and diabetes mellitus.