Among the clinicopathologic parameters analyzed, multivariate Cox regression revealed that the higher serum PSA level (Hazard Ratio (HR) = 2.870, p = 0.004), the lower CD8+ cell count (HR = 3.004, p = 0.018) and the higher CD204+ cell count in the SVI area (HR = 3.290, p = 0.013) are an indication of the unfavorable prognosis of cancers with SVI (Table 2). The gene discussed is KLK3; the disease is cancer.