The detected variants were found in nine genes (COL4A5, DIAPH1, MYO7A, MYO15A, OTOGL, TECTA, TMC1, TMPRSS3, TSPEAR) harbouring four pathogenic variants, three likely pathogenic variants and nine VUS variants associated with hearing impairment. The gene discussed is COL4A5; the disease is hearing loss disorder.