The top 20 FRG1 correlated genes (rs ≥ 0.535) (Supplementary Table S2) and FRG1 were added in multivariate cox regression model using TCGA-MESO (The Cancer Genome Atlas Mesothelioma), TCGA-LUAD (The Cancer Genome Atlas Lung Adenocarcinoma) and TCGA-LUSC (The Cancer Genome Atlas Lung Squamous Cell Carcinoma) datasets. The gene discussed is FRG1; the disease is squamous cell lung carcinoma.