To investigate the prognostic effect of FRG1 using colorectal cancer TCGA-READ (The Cancer Genome Atlas Rectum Adenocarcinoma) and TCGA-COAD (The Cancer Genome Atlas Colon Adenocarcinoma) datasets, the top 20 FRG1 correlated genes (Supplementary Table S2) were added (rs ≥ 0.964) in the multivariate cox regression model (Supplementary Table S3). The gene discussed is FRG1; the disease is colon adenocarcinoma.