By way of comparison with our previous study19 with VEGF-A-PlGF-2123–144, PDGF-BB-PlGF-2123–144 combination in the db/db T2D model, the eGF triple therapy led to more granulation tissue (Fig. 1c) and more extensive would closure (Fig. 1d) at 7 days than did the dual combination therapy. This evidence concerns the gene EGF and type 2 diabetes mellitus.