WEE1 and Immunodeficiency: Moreover, MDA-MB-231 tumour-bearing Hu-HSC-NPG (humanized (Hu)-hematopoietic stem cells transplanted (HSC)-non-obese diabetes, protein kinase DNA-activated catalytic with severe combined immune deficiency, null IL-2 receptor gamma chain (NPG)) model was constructed to further evaluate the anti-tumour effect of PPD plus Zeb in humanized mice.