In agreement with these studies, in a mouse model of systemic candidiasis, Casp1/11-/- mice (Fig. S1a) were more susceptible to C. albicans infection, displaying higher death rates (Fig. S1b), worse clinical scores (Fig. S1c), more severe organ damage (Fig. S1d), and increased fungal burden (Fig. S1e, f) compared to wild-type (WT) mice. Here, CASP1 is linked to candidiasis.