CASP1 and infection: Gsdmd deletion, without affecting the cleavage and activation of caspase 1 (Fig. 1a), conferred partial protection from C. albicans-induced sepsis and disease, as shown by increased survival (Fig. 1b), alleviation of infection-induced body weight loss (Fig. 1c), and improved clinical outcomes (Fig. 1d) in Gsdmd-/- mice.