Given the fact that G3BP1 is an SPOP-interacting protein, we evaluated the prognostic impact of G3BP1 in benign, primary Pca and castration-resistant prostate cancer (CRPC) by tissue microarray (TMA) and immunohistochemistry in 153 independent cases collected at the Weill Cornell Pathology tumor bank. This evidence concerns the gene G3BP1 and neoplasm.