Given the fact that G3BP1 is an SPOP-interacting protein, we evaluated the prognostic impact of G3BP1 in benign, primary Pca and castration-resistant prostate cancer (CRPC) by tissue microarray (TMA) and immunohistochemistry in 153 independent cases collected at the Weill Cornell Pathology tumor bank. This evidence concerns the gene SPOP and posterior cortical atrophy.