Here we explored if inhibition of PYK2 would also improve the intestinal immunopathology in a model of Helicobacter hepaticus infected and anti-IL-10R monoclonal antibodies administered (Hh+anti-IL10R) colitis, which is characterised by IL-23-dependent intestinal inflammation along with a robust T helper type 1/type 17 (Th1/Th17)-polarised effector T cell response40 (Supplementary Fig. 7a). The gene discussed is PTK2B; the disease is colitis.