A previous epidemiological study showed that bone metastasis of breast cancer is common across all the subtypes except the basal-like one45, whereas liver metastasis is enriched in hormone-positive subtypes46 and brain metastasis is enriched in HER2-enriched47 and triple-negative subtypes48, all of which are highly consistent with our organotropic variation enrichment analysis. This evidence concerns the gene ERBB2 and breast carcinoma.