The predictive and significantly more abundant variant of bone-MFP group than that in liver-MFP group is SPOP mutation (p = 0.0007, proportion test), which has been found to represent a distinct subtype of prostate cancer that is mutually exclusive to the common E26 transformation-specific (ETS) transcription family fusions56,57. The gene discussed is SPOP; the disease is prostate carcinoma.