Projecting the OGTORs into a triangular space (Fig. 5a) instead and highlighting the variants with variant fraction larger than 5% and FDR less than 0.05, we clearly showed that the top liver-tropic variant of the breast cancer is ESR1 mutation, the bone-tropic variant is CDH1 mutation, and the brain-tropic variants include TP53 mutation, CDK12, and ERBB2 amplifications. The gene discussed is ESR1; the disease is breast cancer.