PDCD1 and neoplasm: Additionally, the mean SpatialScore was significantly different from that of a random sample in responders (Supplementary Fig. 4k, Supplementary Fig. 4m), but not in nonresponders (Supplementary Fig. 4l, Supplementary Fig. 4n), suggesting that an active process specifically coordinates the spatial interactions of PD-1+ CD4+ T cells, tumor cells, and Tregs in responders.