CD4 and neoplasm: The other CNs were composed of previously unappreciated sub-structures within the dermal infiltrate that were not apparent in the corresponding H&E or fluorescent images, including immune-infiltrated stroma (CN-2, red region), vascularized stroma (CN-4, gray region), tumor and dendritic cells (CN-5, purple region), lymphatic enriched stroma (CN-6, orange region), tumor and mixed immune cells (CN-7, cyan region), tumor and CD4+ T cells (CN-8, yellow region), innate immune cell enriched (CN-9, blue region), and Treg enriched (CN-10, pink region) (Fig. 3c).