To evaluate the therapeutic potential of our in vitro findings, we isolated cancer cells from surgically resected tissues from patients characterized as ABHD5highDPY30lowc-Metlow or ABHD5lowDPY30highc-Methigh (Fig. 7d) and assessed sphere formation in the presence of the c-Met inhibitor Savolitinib (Fig. 7e). The gene discussed is MET; the disease is cancer.