NF1 and cancer: To understand the magnitude of NF1 alterations in human cancers, we used the cBio Cancer Genomics Portal (cBioPortal: http://www.cbioportal.org) to interrogate cancer genomic data for alterations of NF1 in large numbers of tumor samples from cancer studies.NF1 somatic mutation frequency showed in cBioPortal cancer datasets was 6.1%, and there are 903 mutations in patients with multiple samples (Fig. 6A).