CD8+ T cells from Hepa1-6 shGOLM1 tumor exhibited low PD-1 and TIM-3 expression relative to Hepa1-6 shNT tumor, with increased effector cytokines, IFN-γ and GZMB (Fig. 2c and Supplementary Fig. S2b). The gene discussed is CD8A; the disease is neoplasm.