Additionally, we evaluated the functional states of CD8+ T cells in HCC with various GOLM1 levels and found that although no obvious difference was detected in the number and proliferation of CD8+ T cells between GOLM1-low and -high subgroups, their functional states were varied with decreased levels of effector cytokines (IFN- γ and GZMB) and increased expression of inhibitory receptors (PD-1 and TIM-3) in CD8+ T cells from GOLM1-high HCC. The gene discussed is GZMB; the disease is hepatocellular carcinoma.