The neuropathology of PSP is characterized by intracellular aggregates of 4-repeat tau in neurons and glia (2–5); these aggregates are distributed in a progressive sequence starting in the substantia nigra, globus pallidus and subthalamic nucleus, then pons, striatum and the precentral gyrus in the cerebral cortex, before reaching the cerebellum and frontal cortex (6). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.