While acral and mucosal melanomas reportedly have a non-inflamed TME with less efficacy of ICIs,35–37 a Japanese prospective observational study has shown that anti-PD-1 mAb exhibits similar efficacy against these types.34 In our cohort, there was no significant difference in CD8+ T-cell infiltration or CD155 expression among melanoma types. The gene discussed is PVR; the disease is melanoma.