Planned investigations will expand upon the results from these studies with neonatal pigs: 1) by conducting scRNA-seq, snRNA-seq, and other state-of-the-art analyses to continue identifying/validating key regulatory pathways that govern the P1-injury–induced proliferation of neonatal CMs and drive the complete structural recovery of infarcted pig hearts; and 2) by “turning back the clock” in adult heart by using modified RNA or adeno-associated virus 9 to target the expression of CM cell-cycle regulatory molecules and promote remuscularization of adult large mammal hearts after MI. The gene discussed is CLOCK; the disease is myocardial infarction.