All patients showed peripheral eosinophilia (median, 1540 cells/μl), elevated level of IgE (median, 2802 IU/ml) and positive reactions for Aspergillus-specific IgE (median, 20.7 IU/ml; IQR, 0.9–81.2 IU/ml). The gene discussed is IGHE; the disease is Increased total eosinophil count.