Haferlach et al. [10] summarized a total of 944 MDS cases, and found that 80% -90% patients harbored at least one mutation, and the most common mutations were TET2, SF3B1, ASXL1, etc. Zheng et al. [15] reported that 64% (158/247) and 71% (157/221) of the mutations were detected by the 640-gene NGS panel in low-grade and high-grade MDS patients, respectively. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.