According to the updated definition, we identified 24 RS genes in BRCA data set, 25 RS genes in STAD data set, 20 RS genes in HNSC data set and 24 RS genes in METABRIC data set among genes in regulating PD-L1/PD-1 pathway in cancer (93/292), with overlapping genes between each other. The gene discussed is PDCD1; the disease is cancer.