To prove this, Ki67, a proliferative cell-expressed protein that closely related to mitosis and TdT-mediated dUTP Nick-End Labeling (Tunel), a method to detect DNA breakage to reflect the tumor cell apoptosis, were applied to evaluate the efficacy of mild-PTT mediated by ICG@PM@NP in inducing tumor cell death (Fig. 6). This evidence concerns the gene MKI67 and neoplasm.