For example, multiple mouse populations harbor signals of selection associated with autism spectrum disorder and speech-related impairment (e.g., Cntnap2, Trrap, Herc2, Nlgn1, and Nalcn), deafness (e.g., Met, Ubr1, Pcdh15, Ccdc50, Dnmt1, Col11a1, Myo3a, Otogl, Ppip5k2, Slc26a4), diabetes (e.g., Retn, Cel, Hnf4a), glaucoma (e.g., Opa1, Asb10), and intellectual disability (e.g., Auts2, Trmt1, Slc4a4, Trappc9, Kcnk9, Lingo1). The gene discussed is TRRAP; the disease is glaucoma.