For example, multiple mouse populations harbor signals of selection associated with autism spectrum disorder and speech-related impairment (e.g., Cntnap2, Trrap, Herc2, Nlgn1, and Nalcn), deafness (e.g., Met, Ubr1, Pcdh15, Ccdc50, Dnmt1, Col11a1, Myo3a, Otogl, Ppip5k2, Slc26a4), diabetes (e.g., Retn, Cel, Hnf4a), glaucoma (e.g., Opa1, Asb10), and intellectual disability (e.g., Auts2, Trmt1, Slc4a4, Trappc9, Kcnk9, Lingo1). This evidence concerns the gene PPIP5K2 and deafness.