For example, multiple mouse populations harbor signals of selection associated with autism spectrum disorder and speech-related impairment (e.g., Cntnap2, Trrap, Herc2, Nlgn1, and Nalcn), deafness (e.g., Met, Ubr1, Pcdh15, Ccdc50, Dnmt1, Col11a1, Myo3a, Otogl, Ppip5k2, Slc26a4), diabetes (e.g., Retn, Cel, Hnf4a), glaucoma (e.g., Opa1, Asb10), and intellectual disability (e.g., Auts2, Trmt1, Slc4a4, Trappc9, Kcnk9, Lingo1). Here, HERC2 is linked to autism spectrum disorder.