GSK3B and leukemia: Hsa_circ_0121582 is present both in the cytoplasm and in the nucleus, with different functions evident in each of these compartments: in the cytoplasm, it acts as a sponge for miR-224, and in the nucleus, it binds to the GSK3beta promoter to recruit DNA demethylase TET1. The resultant upregulation of GSK3beta expression inhibits the Wnt/beta-catenin signaling pathway, leading to leukemia cell proliferation.