Among the selected miRNAs, mir-99a-3p can regulate bone homeostasis and osteoblast differentiation [56]; mir-382-5p is closely related to the decrease of bone mineral density caused by T2DM [57]; miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the BGN-mediated BMP/SMAD pathway [58]; and mir-188 can inhibit cell formation, promote fat accumulation in the bone marrow, and it significantly increases in elderly patients [59]. This evidence concerns the gene BGN and type 2 diabetes mellitus.