A study explored the effects of CK on liver cancer in HepG2 cells, SMMC‐7721 cells, and mice‐bearing human hepatocellular carcinoma (HCC) xenografts, indicating that CK decreased the DNA‐binding capacity of STAT3 in HepG2 and SMMC‐7721 cells. Here, STAT3 is linked to hepatocellular carcinoma.