A previous study elucidated the cytotoxic mechanism of CK‐induced apoptosis of HT‐29 human colon cancer cells, which demonstrated that CK‐mediated generation of reactive oxygen species (ROS) resulted in apoptosis by modulating the mitochondria‐dependent apoptotic and JNK/p38mitogen‐activated protein kinase (MAPK) pathways (Lee et al., 2010). Here, MAPK8 is linked to malignant colon neoplasm.