We investigated cells after infection with a multiplicity of infection (MOI) 100 for 6 h, conditions at which 100% of cells were positive for translocated Yops (S1A Fig) and a maximal effect on gene expression [36] and histone modifications (S1B Fig) but no signs of cell death as measured by membrane permeability (S1C Fig) and caspase-3 cleavage (S1D Fig) [61,62] are detectable in the human macrophages. The gene discussed is CASP3; the disease is infection.