ACE and myocardial infarction: A large clinical trial, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), did not find a significant association between CCB (amlodipine) or angiotensin-converting enzyme (ACE) inhibitor (lisinopril) versus thiazide diuretic (chlorthalidone) and the risk of GI bleeding [20].