Of particular interest, the expression of BRD4, a known epigenetic activator of LIN28B and IGF2BPs [16, 18], as well as the infant AML signature genes PAX5 and POU2AF1, is significantly up-regulated in infants compared to >5 year olds with AML (Fig 5D). Here, BRD4 is linked to acute myeloid leukemia.