Of note, components of canonical WNT signaling (FZD8, LEF1, WNT10B, AXIN2), the ETS1 transcription factor and its co-activator PAX5 [4], and the stem-cell and fetal B cell developmental gene LIN28B [5, 6] are expressed at distinctly higher levels in infants compared to older children with AML (Fig 2A, inset shows high correlation between PAX5 and ETS1 mRNA levels). The gene discussed is AXIN2; the disease is acute myeloid leukemia.