As shown in Fig 6, BRD4 and its putative targets LIN28B, IGF2BP3, and POU2AF1 all show highly significant patterns of de-methylation in infants (Bonferroni-Holm adjusted p-values for all shown CpG probes are < 0.05), as does ETS1, which is highly up-regulated in infant AML (Fig 2) and targets half of the genes in our infant AML signature. This evidence concerns the gene BRD4 and acute myeloid leukemia.