NPPA and hypertensive disorder: The results of this study: 1) provide further validation that HumMod accurately reproduces responses to physiological interventions and support the utility of using the virtual population approach to elucidate mechanistic insight into HTN therapy, 2) suggest several baseline physiological factors of importance that predict the antihypertensive response to BAT, 3) suggest that suppression of RSNA and increases in ANP secretion contribute but, independently, are not obligatory factors for BP lowering with BAT, unless both are blocked simultaneously.