At baseline, the virtual population presented with HTN, increased cardiac output, increased circulating levels of ANG II and aldosterone, glomerular hyperfiltration, increased renal sodium reabsorption, and greater peripheral and renal SNA relative to normal (Tables 1 and 2), similar to humans with obesity-mediated HTN [3, 24, 35, 36]. The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.